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Zinc: indications in brain disorders

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    Fundam Clin Pharmacol, 2015
    Zinc: indications in brain disorders
    Prakash, A; Bharti, K; Majeed, AB
    Zinc is the authoritative metal which is present in our body and reactive zinc metal is crucial for neuronal signaling and is largely distributed within presynaptic vesicles. Zinc also plays an important role in synaptic function. At cellular level, zinc is a modulator of synaptic activity and neuronal plasticity in both development and adulthood. Different importers and transporters are involved in zinc homeostasis. ZnT-3 is a main transporter involved in zinc homeostasis in the brain. It has been found that alterations in brain zinc status have been implicated in a wide range of neurological disorders including impaired brain development and many neurodegenerative disorders such as Alzheimer's disease, and mood disorders including depression, Parkinson disease, Huntington disease, amyotrophic lateral sclerosis, prion disease. Furthermore, zinc has also been implicated in neuronal damage associated with traumatic brain injury, stroke, and seizure. Understanding the mechanisms that control brain zinc homeostasis is thus critical to the development of preventive and treatment strategies for these and other neurological disorders. This article is protected by copyright. All rights reserved.

    This article is protected by copyright. All rights reserved.
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