Calorierestrictionmimetics...sirtuins,etc.Startingtodiveintoawholenewoceanofunfamiliarterms,processes,andheapsofdata.Howtogetthehealthbenefitsoffasting(avoidingthedownsides),chemically?Dr. Sinclair has 77 different publications in PubMed telling something about sirtuins. This paper below is a review but it is not a free paper. He has now bought Prana, changed it to Alterity Therapeutics. He must believe that PBT434 ( or also PBT2 ) will make a difference in sirtuin modulation and aging.
Strangely,haverecentlynotedthementionoffastingmakingsubtlealterations(hmmm...perhapsduetothesirtuins)thatholdsomenegativeprocessesatbay,indisparatepublications.UnitingwithDavidSinclairseemstohavethepotentialtoopen"interestingdoors."Lookingforwardtothejourney.
Abigthankyoupivalde,forinitiatingtheintegration.
Other:WeseemtobemissingaSkint,M1...,Pierre,etc.andotherkeycontributors.I'mhopingyoufolkshaven'tsuccumbedtotallglassesdrippingcondensationwithlittleumbrellasbobbingupanddown.AlsohopingsomeluminariesfromSinclair'sother"alliedentities"willjointheconversation.
'noughsaid...
Here you can find the sirtuin publications by Dr. Sinclair : https://www.ncbi.nlm.nih.gov/pubmed/?term=Sinclair+DA%2C+sirtuinPharmacol Ther. 2018 Aug;188:140-154. doi: 10.1016/j.pharmthera.2018.03.004. Epub 2018 Mar 22.Sirtuin activators and inhibitors: Promises, achievements, and challenges.
Abstract
The NAD+-dependent protein lysine deacylases of the Sirtuin family regulate various physiological functions, from energy metabolism to stress responses. The human Sirtuin isoforms, SIRT1-7, are considered attractive therapeutic targets for aging-related diseases, such as type 2 diabetes, inflammatory diseases and neurodegenerative disorders. We review the status of Sirtuin-targeted drug discovery and development. Potent and selective pharmacological Sirt1 activators and inhibitors are available, and initial clinical trials have been carried out. Several promising inhibitors and activators have also been described for other isoforms. Progress in understanding the mechanisms of Sirtuin modulation by such compounds provides a rational basis for further drug development.
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