"Whole-exome sequencing of 21 women with various hormone receptor and Her2 status revealed frequent alterations of the CDK and PI3K pathways [8••]. The PI3K pathway is frequently altered in brain metastases from breast cancer with changes often unique to the brain metastasis [8••]. These findings suggest the potential for use of CDK and PI3K inhibitors as a therapeutic avenue for treatment of brain metastases with these genetic alterations." (PB Paid paper 6th of May published
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