RE: anti-AIDS drugprevents release of AIDS23/5

BIOTRON LIMITED 2002-05-23 ASX-SIGNAL-GHOMEX - Sydney
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The Directors are pleased to advise that Biotron Limited ('Biotron')
has demonstrated that the Company's Virion Project lead compound,
BIT009, inhibits HIV-1 replication in infected human cells.
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The inhibition of HIV-1 replication prevents a rise in virus titre
and the development of AIDS. As existing AIDS drugs do not target
this 'budding' process, the results of Biotron's research provide a
way to develop a new type of drug which can be used in the treatment
of AIDS.
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Professor Peter Gage, the Company's Research Director believes that
the results represent a major step in the development of a new kind
of anti-AIDS drug that prevents release of the AIDS virus from cells.
He said: "The results are exciting and very satisfying and confirm
the approach the Company is taking."
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VIRION PROJECT
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In HIV-1 assays, which were performed on behalf of the Company at the
Westmead Millenium Institute, a leading Australian research
institute, BIT009 was shown to inhibit HIV replication in primary
human macrophages. Preliminary studies indicate that the HIV-1 virus
does not easily generate resistant mutants to these compounds in the
experiments performed. Work is on-going to further characterise the
effects of the compounds on replication of HIV-1.
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This result demonstrates proof-of-concept of Biotron's anti-HIV drug
discovery platform. BIT009 was identified as a potential anti-HIV
drug candidate using Biotron's patented method for determining ion
channel activity (US 6355413) which identifies inhibitors of the
HIV-1 Vpu protein. Vpu is a protein that forms ion channels in
cellular membranes, and Biotron has shown that inhibition of Vpu ion
channel activity also depresses 'budding' or release of new virus.
This finding was recently published in the European Biophysics
Journal.
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Using the information obtained from this research, Biotron is now
designing additional novel compounds that act on the HIV-1 Vpu
protein. In addition, Biotron is expanding this platform by
developing a second novel screening assay to further facilitate
identification of drugs that depress viral budding. This unique HIV
drug discovery platform will enable Biotron to rapidly screen
externally sourced libraries of compounds in addition to those
developed in-house, thereby providing a whole new therapeutic target
for AIDS that has previously not been possible.
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Professor Gage also said: "These results represent a major advance in
the fight against AIDS and provide proof-of-concept of Biotron's HIV
drug discovery platform technology. We expect that new drugs, based
on the Company's technology, will now be developed to stop the HIV-1
infection from developing into AIDS."
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For further information, please contact Dr Michelle Miller on
(02) 6125 8001 or 0412 313 329.
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P J NightingaleCOMPANY SECRETARY
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(no comment--other than to say stggering--LOL)
BIT Biotron Ltd FPO

Total Trades Total Volume Last Trade V.W.A.P*
105 914,137 57 46.7
* Volume Weighted Average Price
Trade
Number (s) Time
Last Traded Price Volume Change Value Number
of Trades
103 - 105 4:47:15 pm 60 26,067 3 $15,640 3
102 4:22:16 pm 63 10,000 3 $6,300 1
100 - 101 4:20:37 pm 60 17,000 3 $10,200 2
77 - 99 4:13:11 pm 57 168,149 3 $95,845 23
75 - 76 3:59:54 pm 54 20,000 1 $10,800 2
74 3:59:34 pm 53 2,000 1 $1,060 1
73 3:59:32 pm 52 30,000 1 $15,600 1
71 - 72 3:59:20 pm 53 10,000 3 $5,300 2
70 3:58:46 pm 50 3,000 5 $1,500 1
68 - 69 3:58:45 pm 55 18,000 3 $9,900 2
67 3:58:45 pm 52 25,000 1 $13,000 1
66 3:58:45 pm 51 7,000 1 $3,570 1
63 - 65 3:58:44 pm 50 42,000 1 $21,000 3
62 3:58:09 pm 49 10,000 1 $4,900 1
57 - 61 3:57:22 pm 48 61,643 0.5 $29,589 5
51 - 56 3:57:03 pm 47.5 35,784 2.5 $16,997 6
50 3:54:54 pm 45 2,000 2.5 $900 1
49 3:54:40 pm 47.5 2,000 2.5 $950 1
47 - 48 3:54:32 pm 45 28,000 5 $12,600 2
36 - 46 3:52:48 pm 50 32,423 1 $16,212 11
35 3:48:50 pm 49 5,000 1 $2,450 1
33 - 34 3:48:50 pm 48 12,500 4 $6,000 2
31 - 32 3:47:17 pm 44 4,000 4 $1,760 2
25 - 30 3:41:37 pm 40 42,650 1 $17,060 6
24 3:39:36 pm 39 10,000 1 $3,900 1
20 - 23 3:38:50 pm 40 52,350 1 $20,940 4
17 - 19 3:35:18 pm 41 40,000 1 $16,400 3
10 - 16 3:34:17 pm 40 52,500 2 $21,000 7
9 3:31:29 pm 38 17,650 2 $6,707 1
8 3:31:18 pm 36 17,800 2 $6,408 1
7 3:31:10 pm 34 12,000 1 $4,080 1
3 - 6 3:31:00 pm 33 32,621 5 $10,765 4
2 12:29:12 pm 28 45,000 1 $12,600 1
1 11:33:03 am 27 20,000 $5,400 1
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