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Progress of Israel R/R AML trial

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    Created this new thread to keep the Chart thread on-topic.

    ( see this post for background: https://hotcopper.com.au/posts/42690928/single )

    From clinicaltrials.gov first patient was effectively enrolled 19 July 2019.

    https://clinicaltrials.gov/ct2/show/NCT03820908?term=Bisantrene&draw=2&rank=1

    Screen Shot 2020-02-01 at 2.15.13 pm.png

    Then we had ASX announcement 25 July 2019. Announcement occurred after completion of first 7-days of treatment (with no complications).

    https://www.asx.com.au/asxpdf/20190725/pdf/446w20y5617czz.pdf

    Screen Shot 2020-02-01 at 2.18.35 pm.png

    Reading the study design they first receive a 7-day course of Bisantrene,. There is also a 3-day consolidation treatment after Complete Response (optional).


    Screen Shot 2020-02-01 at 2.25.14 pm.png

    @RaceOncology reading the two historic paediatric cases with long term survival I note one patient received a lower dose 5-day course at 200mg/m2/day and the other received a 7-day 250mg/m2/day course.

    In the investigator-lead trial they are going for a longer 7-day course plus an additional optional 3-day consolidation course. That additional consolidation course is interesting ... seems to be like a booster measure to minimise risk of relapse.

    Has the 3-day consolidation course been added due to specific findings from previous Phase II studies?


    Screen Shot 2020-02-01 at 1.05.10 pm.png
 
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