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Parkinsons disease, please help if U can

  1. Hi eveyone,

    I am concerned for an elderly person who appears to suffer from symptoms similar to parkinsons. nb. It may not be parkinsons. The current specialist become agitated & upset when I first suggested some of the personal research I had done, including the following knowledge I recieved from the net, nevethless, he appears to be more concerned with his "ego status" rather than seeking truth and implementing effective solutions. He has presribed levodopa for over 12 months now and there has been no effect whatsoever imho, in fact it has become worse & may even be slightly better without the drug imho.

    If any doctors, medical people or sufferers out there can share their experiences, this would help greatly. I have organised another specialist for second opinion, and will give him 2 months, if he fails to enlighten us, will try another and another and another.

    Past help from good HC people in 2001 for which I am eternally grateful;

    =========

    GP

    I recollect seeing a post by you some weeks ago about an acquaintance suffering from Parkinson's; the following Science News item from the ABC's website (www.abc.net.au) may be of interest especially if he/she is not a caffeine consumer.

    Although it is stated that it is too early (on the basis of the experiments with mice detailed below) to recommend an increase in caffeine consumption to prevent or slow the disease, nevertheless a study of people with Parkinson's is planned so who knows what will come of it, might be worth a try if your friend's doctor has no problems with it.

    Cheers


    STARTS

    Caffeine fix may reduce risk of Parkinson's
    Wednesday, 16 May 2001


    A coffee a day ... ?

    Forget that double decaff, new research suggests caffeine can reduce the risk of Parkinson's disease.

    Scientists at Massachusetts General Hospital have shown caffeine is able to prevent the loss of the chemical signal that is depleted in Parkinson’s disease.

    The research, published in the Journal of Neuroscience , links caffeine's effects in mice to the A2A receptor located on neural cells next to those that degenerate in Parkinson's patients.

    These receptors are found in distinct areas of the brain and their expression is restricted to the cells that are targets of the dopaminergic neurons that go awry in Parkinson's disease.

    Dopamine replacement is the usual treatment for Parkinsons's disease, but it does have side effects.

    "The A2A receptor has a distinct advantage when it comes to treatment because it exists for the most part where you want to target your therapy. So there may be fewer side effects," said team leader Dr Michael Schwarzschild.

    The scientists found caffeine acts as an antagonist to the A2A receptor, blocking its binding site and rendering it inactive. However, the team does not yet understand how this prevents the loss of cells that produce dopamine.


    Two cups a day

    Schwarzschild and his team used the chemical MPTP for a mouse model that caused the depletion of the neurotransmitter dopamine to mimic the symptoms of Parkinson's disease.

    When the mice were given the equivalent of one to two cups of coffee, their brain dopamine levels remained near normal, and the MPTP toxicity was decreased. The Parkinson-like symptoms induced by the chemical were also reduced.

    "The animal results lend more weight to caffeine's neuroprotective nature," Schwarzschild said. "But the results dont prove it, and they do not provide a rationale for changing caffeine consumption habits."

    The study does not prove that caffeine can prevent or treat the symptoms of Parkinson's, said the research team's co-director Jiang-Fan Chen. But he said there is a clear relationship between moderate caffeine consumption and a reduced risk of Parkinson's.

    "If caffeine is protective through the A2A receptor, more discrete targeting of this receptor may be a good therapy," Schwarzschild said.

    The team now plans to study people with Parkinson's to see if caffeine consumption slows down the progress of the disease.

    ENDS

    ===========================

    In addition to the info already posted,selegiline hydrochloride(eldepryl) is often prescribed along with L-dopa.It can extend the period of efficacy of L-dopa treatment,unfortunately the effect does eventually diminish.Eldepryl,or Deprenyl as it is known in the States and Europe,is also a popular anti-aging drug.Healthy folks use it to maintain optimal dopamine metabolism in the brain.If you go to www.lef.org you can search for info on Parkinsons/Alzheimers treatments,and info on smart drugs.

    ======================

    Unfortunetely there is no cure for Parkinsons.

    Levodopa is the commonest drug given to parkinsons patients. It replaces the Dopamine in the brain (parkinsons patients have low dopamine). The drug must be in combination with Benserizide (madopar) or carbidopa (sinemet)to stop the drug being metabolised before it reaches the brain. Without this, levodopa is useless.

    Levodopa is also one drug which loses its ability to control parkinsons after a certain time (around 5 years, but dependent on dose). This is the biggest problem with its use.

    Comtan (entacapone) - is on the australian market and parkinson users can use it in combination with levodopa, so the dose of levodopa can be reduced.

    There are also a few other drugs on the market that focus on the different problems of keeping Dopamine in the brain.

    Youll find stacks of information on the net.
    Probably the best place to start having a look. Good luck.

    ===============

    A great deal of medical information is available on the net at;
    www.mediconsult.com

    ================

    There are many forms of the disease and some people even benefit from brain surgery.

    As time goes on, certain lifestyle and dietary choices are being found to have been a contributing factor, as well as chemical exposure, but this varies widely from person to person and is not yet well understood.

    One reason I like BGN so much is its efforts in this area. However, much of the research is understandably controversial because of the techniques used and what they are used on. BGN is not alone in being hampered in this regard and has recently had to move partly offshore to enhance its ability to bring solutions to market.

    Very temporary relief and "normality" is possible for some sufferers without the use of drugs and surgery eg. shocking a sufferer who cannot swim by throwing them in a pool or providing an emotional experience which is extremely positive. I am not being so callous as to suggest such action be taken, but rather mentioning something which is one of many observations providing clues for potential solutions one day.

    Disclaimer: I don't own any BGN shares at the moment.

    ======================

    I always thought one cause came from prolonged exposure to Aluminium.

    Doctors can test your blood and give you an aluminium level.
    Black "death" Gold. Well killer, Kiss of Death, Lord of the waste lands, Black Troll down a hole.

    ================

    http://www.abc.net.au/rn/talks/8.30/helthrpt/promo.htm

    "Stem Cell Research - Separating The Hype From The Reality

    Monday 9/04/01 at 8.30am, repeated 8.30pm
    This week on the Health Report, stem cells - those cells which can grow into
    liver or heart or brain or in fact any tissue you like. We'll try to
    separate the hype from the reality, especially in Parkinson's disease."

    May be of interest. ABC transcripts are normally available on the site
    some hours after the broadcasts. Good luck.

    =============

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