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novogen's promensil is the new viagra for older wo

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    New study finds red clover isoflavone supplement may help alleviate sexual discomfort
    Tuesday, 8 July 2003

    New study finds red clover isoflavones may help vaginal dryness in women aged 45 to 65.

    London. 5 July 2003. Results of a prospective, double-blind, placebo controlled trial released today by King’s College Hospital London, indicate that a red clover isoflavone supplement (Promensil®) may be a natural alternative to hormone replacement therapy (HRT) for minimising vaginal atrophy in healthy, postmenopausal women.

    Atrophic vaginitis is a condition in which the vagina becomes dry and overly delicate in response to declining levels of oestrogen at the menopause and beyond. About 1 in 2 women have some symptoms related to atrophic vaginitis after the menopause1. A normal part of ageing, the condition can be managed to help women avoid everyday discomfort and continue to enjoy sex.

    The research, led by Consultant Gynaecologist Dr Malcolm Whitehead, found that 80mg of Promensil significantly improved the vaginal maturation index (VMI), a measure of normal functioning of the epithelium lining the vagina, compared to placebo while there was no increase seen in endometrial thickening for either the Promensil or placebo groups.

    “The preliminary results of this study are encouraging news for women who want to manage the menopause naturally and to continue enjoying sex,” said Dr Whitehead, Director of the Gynaecology / Endocrinology Unit, King’s College Hospital London.

    “Unlike steroidal oestrogens, the natural isoflavone phytoestrogens or plant oestrogens provided by the redclover supplement are showing a selective oestrogen receptor modulator (SERM)-like effect i.e. giving a welcome oestrogenic effect in relieving vaginal dryness while showing no adverse thickening effect on the endometrium,” Dr Whitehead said.

    This study complements two further randomised placebo controlled studies published last year demonstrating that the daily use of Novogen Redclover significantly decreases hot flushes in postmenopausal women 2,3.

    Promensil is a natural dietary isoflavone supplement derived from redclover for women during and after the menopause. Standardised to pharmaceutical grade Good Manufacturing Practice (GMP) levels, it is a rich source of the four major dietary isoflavones known to be bioactive. Promensil has been studied more extensively and rigorously than any other similar dietary supplement including those based on soy, that contain only two out of the four isoflavones found in red clover.

    The aim of the King’s College Hospital study was to evaluate the efficacy and safety of Promensil versus placebo on endometrial thickening, uterine blood flow and the vaginal maturation index. A prospective, randomised, double blind, placebo controlled, cross-over trial with two 8-week phases was conducted. Twenty-nine women, age 45-65 received either 80mg of Promensil daily or placebo for the first active phase of eight weeks, followed by a 2 week ‘wash-out’ on placebo and an additional eight weeks on the reverse treatment. No adverse side effects were reported during the study.

    King’s College Hospital London is a major London teaching hospital serving a diverse local, regional, national and international population. More than 1,000 research projects directed by 600 researchers are currently underway at the facility. The hospital is affiliated with the University of London and has its own Menopause Clinic dedicated to helping women manage the symptoms they experience from the pre through to post-menopause.


    References
    1 Atrophic vaginitis leaflet. Prodigy, NHS. November 2002.
    2 Van de Weijer PHM, Barentsen R. Isoflavones from red clover (Promensil) significantly reduce hot flashes compared with placebo. Maturitas 2002; 42: 187-193
    3 Jeri AR. The effect of isoflavone phytoestrogens in relieving hot flushes in Peruvian postmenopausal women. The Female Patient 2002; 27: 35-37
 
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