KZA 15.6% 44.5¢ kazia therapeutics limited

novogen's jewels

  1. 22,691 Posts.
    I want to do a series of about 7 posts which ought to give a good background to NRT. Starting with:



    1. History. A preliminary trial was held. Sample size was only 6 patients but the trial was 100% successful. Report dated 9 Sept. 2002:

    Relevant extracts:

    1. The objective of the trial was to determine the effects of NV-04 on widening of blood vessels (dilation).

    Dilation enhances blood flow and can reduce blood pressure.

    According to Dr Jaye Chin-Dusting, head of the Baker Institute Vascular Pharmacology Laboratory, who conducted the study at the Alfred Hospital, in Melbourne, the trial results have demonstrated outstanding potency of the drug and reproducibility in arterial dilation by enhancing the biochemical activities within the blood vessel wall.

    "In this study six out of six subjects responded favourably in that intra-arterial administration of the drug led to significant increase in blood flow," Dr Chin- Dusting said.

    2. "These data are consistent with previous results conducted by the Baker team which demonstrated that compounds in the NV-04 program promote blood vessel relaxation, act as antioxidants and inhibit smooth muscle cell growth in blood vessels, factors contributing to build up of obstructive vascular plaques or atherosclerosis.

    "Reduced dilation of arteries is part of the disease process in patients with heart disease, high blood cholesterol and diabetes".

    "These compounds are expected to be sufficiently safe to be administered over long periods without side effects".

    Notes: "Atherosclerosis":

    Comment: This is big business. Professor Husband mentions a $US17.7 vascular drug market in the US alone, say $US45 bill+ if Europe and Japan are included.

    It is earmarked for trials shortly.

    This is just one of Novogen's products--See post 6876


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