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New Prana Patent - 8-HYDROXY QUINOLINE DERIVATIVES

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    8-HYDROXY QUINOLINE DERIVATIVES
    Document Type and Number:
    United States Patent Application 20150025108
    Kind Code: A1

    Abstract:
    The present invention describes a method for the treatment of a neurological condition in a subject which comprises administering to a subject in need thereof a therapeutically effect amount of a compound of the formula
    or pharmaceutically acceptable salts, hydrates, or solvates thereof.

    Inventors:
    Barnham, Kevin Jeffrey (Victoria, AU)
    Gautier, Elisabeth Colette Louise (Victoria, AU)
    Kok, Gaik Beng (Victoria, AU)
    Krippner, Guy (Victoria, AU)
    Application Number: 14/510756
    Publication Date: 01/22/2015
    Filing Date: 10/09/2014
    15. A method for the treatment of Alzheimer's disease in a subject which comprises administering to the subject a therapeutically effective amount of a compound of the formula or pharmaceutically acceptable salts thereof, in which R1 is H; R2 is optionally substituted phenyl; optionally substituted naphthyl; optionally substituted tetrahydronaphthyl; optionally substituted biphenyl; optionally substituted heterocyclyl; COR6; CSR6; CN; (CH2)NR9R10; HCNOR9; HCNNR9R10; OR11; SR11; NR11R12 or SO2NR13R14; in which R13 and R14 are either the same or different and selected from H, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted aryl or optionally substituted heterocyclyl; and R6 is H, C1-6 alkyl, optionally substituted C2-6 alkenyl, hydroxy, optionally substituted aryl, optionally substituted heterocyclyl, SR7 or NR7R8; R7 and R8 are either the same or different and selected from H, optionally substituted C1-6 alkyl, optionally substituted C2-6 alkenyl, optionally substituted aryl and optionally substituted heterocyclyl; R9 is H, optionally substituted C1-6 alkyl, optionally substituted C2-6 alkenyl, optionally substituted aryl or optionally substituted heterocyclyl; R10 is hydrogen, methyl, propyl, isopropyl, butyl, isobutyl, sec-butyl, tert-butyl, pentyl, neopentyl, hexyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, optionally substituted C2-6 alkenyl, optionally substituted aryl or optionally substituted heterocyclyl; R11 is H, optionally substituted C1-6 alkyl, optionally substituted C2-6 alkenyl, optionally substituted aryl or optionally substituted heterocyclyl or together with R12 form optionally substituted heterocyclyl; R12 is optionally substituted C1-6 alkyl, optionally substituted C2-6 alkenyl, optionally substituted aryl or optionally substituted heterocyclyl or together with R11 form optionally substituted heterocyclyl; R3, R and R′ are either the same or different and selected from H, optionally substituted C1-6 alkyl, optionally substituted C2-6 alkenyl, optionally substituted C1-6 alkoxy, optionally substituted acyl, hydroxy, optionally substituted amino, optionally substituted thio, optionally substituted sulphonyl, optionally substituted sulphinyl, optionally substituted sulphonylamino, halo, SO3H, amine, CN, CF3, optionally substituted aryl and optionally substituted heterocyclyl; and R4 and R5 are chloro, wherein the optional substituent is C1-6 alkyl, CF3, fluorine, chlorine, iodine, cyano, C1-6 alkoxy, 5 or 6-membered aryl, heteroaryl, amino or C1-6 alkylamino.
 
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