MSB 0.00% $1.60 mesoblast limited

Not sure if this has been posted before however it deserves a...

  1. 2,489 Posts.
    lightbulb Created with Sketch. 647
    Not sure if this has been posted before however it deserves a new thread.

    https://www.nature.com/articles/s41409-021-01442-3?proof=t%2525C2%2525A0Some interesting discussion on the other site .

    yesterday
    The mechanism of action of MSCs in reducing GVHD is not entirely clear and may be multifactorial. In vitro, MSCs have several immunomodulatory properties and reduce the secretion of inflammatory cytokines such as IFNγ and TNFα by alloreactive T cells [8]. In vivo, infusion of MSCs reduced the expansion of donor T cells and reduced damage in target organs in experimental GVHD models [9]. It is possible that remestemcel-L exerts its beneficial effect through a number of mechanisms, including wound healing properties in the GI tract, since the analysis of MAPs shows that GI crypt damage was quite extensive at the initiation of remestemcel-L therapy and that the large majority of these study patients not only experienced clinical responses within 28 days but 87% were able to discontinue immunosuppressive therapy within 6 months [1].

    In summary, nearly one half of pediatric patients with SR acute GVHD at the initiation of remestemcel-L therapy were diagnosed with severe lower GI disease as measured by MAP, and 64% of these patients survived, compared to 10% of patients with SR acute GVHD and high MAPs from the MAGIC database. These findings support and extend the recently published results that showed that children with severe, SR acute GVHD benefit from remestemcel-L therapy.
    Brilliant !

    Look at the response rate and consider how easy it would be to make sure that every batch has the required efficacy that the FDA mandate. Out of every 10 people treated just 1 patient may have responded with out our treatment .

    Is this the reason SI is so confident?
    Justified in my opinion.
 
watchlist Created with Sketch. Add MSB (ASX) to my watchlist
(20min delay)
Last
$1.60
Change
0.000(0.00%)
Mkt cap ! $1.037B
Open High Low Value Volume
$1.63 $1.65 $1.59 $2.830M 1.756M

Buyers (Bids)

No. Vol. Price($)
4 11765 $1.60
 

Sellers (Offers)

Price($) Vol. No.
$1.61 386 1
View Market Depth
Last trade - 16.10pm 18/10/2021 (20 minute delay) ?
(live)
Last
$1.60
  Change
0.000 ( 0.57 %)
Open High Low Volume
$1.64 $1.64 $1.59 268343
Last updated 15.59pm 18/10/2021 (live) ?
MSB (ASX) Chart
arrow-down-2 Created with Sketch. arrow-down-2 Created with Sketch.