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letter to cdc us re - h1n1 and h274y

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    From: Peter K.C. Cheng, Amanda P.C. To, Tommy W.C. Leung, Peter C.K. Leung, Connie W.C. Lee, and Wilina W.L. Lim
    Author affiliation: Department of Health, Hong Kong, People's Republic of China

    ...Along with pandemic (H1N1) 2009, seasonal influenza viruses continue to circulate in Hong Kong (3). An alarming proportion of the circulating seasonal influenza A virus (H1N1) became resistant to both oseltamivir and amantadine in a short span of 1 month. Oseltamivir-resistant A/Brisbane/59/2007-like clade 2B virus that had reassorted with A/Hong Kong/2652/2006-like clade 2C virus had apparently spread in the community and to other regions of the world. The possibility of reassortment with pandemic (H1N1) 2009 virus is a major concern. Resistance to oseltamivir of pandemic (H1N1) 2009 virus will compromise its use in treatment and render the billion-dose stockpile useless.....
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