KZA 5.13% 41.0¢ kazia therapeutics limited

Genomic Testing - Most Approprate Cancer Treatment

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    There is no question that genomic testing in people suffering from cancer today - is about determining what is the best treatment approach to be taken. Cancer medication is determined based on the study of the DNA of cancer patients. (Such is the rapid advances being made into the use of targeted drug treatments in 2019. see story at very bottom)

    DNA sampling/sequencing most accuracy identifies the cancer type/mutation and allows use of the best cancer drugs available to treat specific cancers. Subsequent to treatment - DNA sampling is then undertaken to monitor DNA changes - hopefully with reduced cancer.

    Pre clinic studies use mouse models to study the before /after effects of DNA methylation - the changes in the mouse DNA are more important than actual mouth responses, these days. Confidence levels have grown in pre clinic as a result of the ability to assess individual cell DNA changes and response to targeted drugs and pathway inhibition. (PI3K)

    GDC 0084 has been selected, for what is referred to as a Genomically-Guided Treatment Trial in Brain Metastases.

    It would seem little point, that the sponsors NCI...... of this "genomics" trial would set out to do determine DNA sequencing in a drug that does not work.

    With collaborators, the NCI has full assess to current GDC 0084 clinical is time now, for the US Government's National Cancer Institute to initiate a dynamic trial.... to bring a drug to market, which effectively shuts down PI3K pathways (a critical cancer carrying enzyme transporter).

    There is no other investing opportunity like this (based on brokers $2 SP report)

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