KZA 1.30% 39.0¢ kazia therapeutics limited

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    nice work again H...

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    GDC-0084 significantly reduced the growth of all DIPG cell lines regardless of whether they harboredPI3K mutations

    (p=<0.001), and were significantly more cytotoxic than the mTORC1 inhibitor Rapamycin (p=<0.01). DIPG cell lines were also more sensitive to PI3K inhibition by GDC-0084 compared to GBM cell lines (n=4, p=<0.001) highlighting the therapeutic potential of GDC-0084 for the treatment of DIPG

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