Very good point.
Though they have already indicated that 20mg is what they are doing, which is in line with the success that came from Xanahes. The target occupancy will reveal all. Potentially the 5mg cohort showed enough enzyme saturation for it to be okay?
10 mg once daily trends at 13mg at time of ingestion down to 6.6mg at 12 hours and then right before the next dose it is as low as 3mg.
it is no wonder XanADu was a failure despite 10mg saturation levels.
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