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    Moving forward and reversing wrinkles

    By Caitlin Trujillo

    Senior Staff Writer


    Published: Thursday, March 11, 2010

    Updated: Sunday, March 14, 2010

    Isis Biopolymer, Inc. moved into the severe, sandy-colored building at 233 Richmond St. this past November. The facility, previously home to a watch-making company, now ticks out about 6,500 transdermal drug delivery patches a day. Come this May, it will be both a bustling factory and full-fledged research lab with a staff of about 70, said Chief Commercial Officer Shawna Gvazdauskas.

    It is this the ability to conduct research and development while simultaneously putting a product on the market that makes Isis Biopolymer stand out, she said. Thats what really makes us so unique.

    Isis Biopolymer is the developer of the IsisIQ platform of drug delivery patches. The patches use three technologies: a selective barrier membrane, a single electrode and hydrogel. Patients can receive up to three different drugs from a single patch.

    Conventional products often have two electrodes and consequently can over-deliver the drug, Gvazdauskas said. The IsisIQ, instead, operates at a low current and can halt the drug delivery process. The platforms patches work by active delivery, meaning patients can control how much of the drug they receive by pressing a button to increase the dosage.

    By virtue of the materials and process of manufacturing, its an extremely flexible platform, Gvazdauskas said.

    Isis Biopolymer uses its Jewelry District location and proximity to medical institutions to its advantage. Browns Molecular Medicine building and Lifespan are within walking distance.

    The company leases its building from the University and works with Lifespan to conduct clinical testing of its products. Across the street sits 222 Richmond St., which will become the home of Browns Alpert Medical School.

    Isis Biopolymers Wrinkle Free Brow Patch went on the market in January under the brand name of University Medical Pharmaceuticals. The company is developing a similar patch for the eye area that will be ready in June, Gvazdauskas said.

    Less than two weeks ago, the company appointed Brown Professor of Emergency Medicine Bruce Becker 78 to the position of director of clinical research. He will supervise various research projects, including a new product to numb pain and work toward the elusive pain-free hospital experience, he said.

    Gvazdauskas said it was an anomaly that the company would manufacture in the
    United States, let alone in Providence. But the location is a huge strategic advantage and creates an opportunity to forge really, really cool partnerships with Brown, the city and Lifespan, she said.

    Isis Biopolymer began in Warwick, R.I. in 2006 but was recruited by the cities of Providence and Cranston in Rhode Island as well as Annapolis, Md.

    Though Annapolis offered attractive incentives, Gvazdauskas said, Providence Mayor David Cicilline 83 as well as Brown President Ruth Simmons launched the best campaign. Cicilline has visited the headquarters several times and has been very supportive, Gvazdauskas said. Ultimately, the lure of working in Providences Jewelry District surpassed Annapolis appeal.

    Were really looking for this to be a microcosm of medical research and development and commercialization, Gvazdauskas said.
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