(E,E)-bisantrene has only one main mechanism of action - G4...

(E,E)-bisantrene has only one main mechanism of action - G4 stabilisation. The reason it has so many effects on cancer cells is that G4 stabilisation controls the expression of a wide range of genes including MYC. One MOA, many anticancer effects.

We know bisantrene works as an anticancer drug, we know the concentration of bisantrene in patients, and we know the concentrations of bisantrene required to inhibit MYC. The concentration of bisantrene in patients is much higher than the concentration required to inhibit MYC expression. Given we know the drug is reaching the tumour in patients, you would have to come up with some ludicrous theory that would break the laws of physics for bisantrene to claim MYC is not being inhibited in patients.

You could argue that MYC inhibition is not important in cancer treatment, but then you would be arguing with over 50,000 scientific papers that claim otherwise.