ATH 25.0% 0.5¢ alterity therapeutics limited

In reading over the review of melatonin, this paragraph...

  1. 114 Posts.
    In reading over the review of melatonin, this paragraph particularly struck me.

    Melatonin has a protective effect on the cholinergic system. It prevents the peroxynitrite-induced
    inhibition of choline transport and ChAT activity in synaptosomes and synaptic vesicles [126].
    Melatonin treatment of eight-month-old APP695 transgenic mice significantly improved the profound
    reduction in ChAT activity in the frontal cortex and the hippocampus [81]. Melatonin also antagonizes
    the spatial memory deficit and the decreased ChAT activity found in adult ovariectomized rats [127].
    However, in rats perfused intracerebroventricularly with Aβ for 14 days, melatonin was unable to
    restore ChAT activity [128]. Melatonin inhibited lipopolysaccharide- and streptozotocin-induced
    increase in AChE activity [129]. Recently hybrids of the AChE inhibitor tacrine and melatonin were
    synthesized as new drug candidates for treating AD [130,131]. These hybrids showed better
    antioxidant and cholinergic-preserving activity than tacrine or melatonin alone. The direct intracerebral
    administration of one of these hybrids decreased induced cell death and Aβ load in the APP/PS1
    mouse brain parenchyma accompanied by a recovery of cognitive function [131].

    My thinking is that many of these compounds (such as melatonin, ferulic acid, and curcumin, for instance)/drugs (pbt2, for instance) show efficacy in certain areas in mice and in human beings, but when applied to humans they seem to fall just a bit short when it comes to cognitive function. There may be great potential for hybrids, natural compounds containing multiple antioxidants, and/or compounds that are highly concentrated and can be inhaled almost directly into the brain (various essential oils via aromatherapy) to get you over that last hump.
 
watchlist Created with Sketch. Add ATH (ASX) to my watchlist
(20min delay)
Last
0.5¢
Change
0.001(25.0%)
Mkt cap ! $26.19M
Open High Low Value Volume
0.5¢ 0.5¢ 0.5¢ $27.94K 6.050M

Buyers (Bids)

No. Vol. Price($)
46 57663299 0.4¢
 

Sellers (Offers)

Price($) Vol. No.
0.5¢ 56205001 43
View Market Depth
Last trade - 16.10pm 29/03/2024 (20 minute delay) ?
Last
0.5¢
  Change
0.001 ( 0.00 %)
Open High Low Volume
0.5¢ 0.5¢ 0.5¢ 20524121
Last updated 15.46pm 29/03/2024 ?
ATH (ASX) Chart
arrow-down-2 Created with Sketch. arrow-down-2 Created with Sketch.