Pivalde posted to this that it is not the way to do controlled studies. And we know this is true however, we are left with a placebo group that was a fluke. This is the same data Masters presented in his slide and I took it a step further to calculate what the pvalues SHOULD have been if the placebo wasn't a "fluke" as we are told by the company.
However, it is not enough for me as a shareholder, as someone who has family with AD, to have the company tell us a fluke and move on. There is a problem with the placebo group we are told that is "unprecedented" and I want to know that the company has done their due dilligence in figuring out what that problem(s) is. I want a report from them on what they think happened because clearly a lot of time was lost, a lot of money and its clear to me that PBT2 works (based on analysis like I've done and Masters has done) and should get to the people that need it as soon as we can get it there. Its not enough to say it is a problem and let it go away without addressing it and move on to another study.
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